Notch1 Signaling and Regulatory T Cell Function

Notch1 signaling and regulatory T cell function.

Previous studies have shown that the Notch1 and TGF-beta signaling pathways are mutually re-enforcing. Given recent evidence that regulatory T cell (Treg) effector function is mediated by TGF-beta signaling, we investigated whether Notch1 signaling also participated in Treg effector function. Initial studies showed that Notch1 ligands, particularly Jagged1, are present on Tregs and that, indeed...

Signaling Pathways Involved In T Cell Inhibits Notch1 Signaling: Multiple Notch1 Notch-Regulated Ankyrin-Repeat Protein

Development Signaling Pathways Involved In T Cell Inhibits Notch1 Signaling: Multiple Notch1 Notch-Regulated Ankyrin-Repeat Protein

The plasticity of regulatory T cell function.

Regulatory T cells (T(regs)) can suppress a wide variety of cell types, in diverse organ sites and inflammatory conditions. Whereas T(regs) possess multiple suppressive mechanisms, the number required for maximal function is unclear. Furthermore, whether any interrelationship or cross-regulatory mechanisms exist to orchestrate and control their utilization is unknown. In this study, we assessed...

Dysregulation of TGF- signaling and regulatory and effector T-cell function in virus-induced neuroinflammatory disease

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